This calculator estimates the broth-side film heat transfer coefficient (\(h_o\)) in agitated Newtonian fluids within stirred tank bioreactors, using empirical correlations (Table 7.1). The correlations depend on the heat transfer configuration (cooling coils or jacketed vessel).
The correlations relate the Nusselt number (\(Nu\)) to the Reynolds number (\(Re\)), Prandtl number (\(Pr\)), and a viscosity correction factor:
Nu = C ⋅ Rea ⋅ Pr1/3 ⋅ (μLw / μL)0.14
Where:
- Nu = ho dT / kT (Nusselt Number - dimensionless heat transfer)
- Re = di² N ρL / μL (Reynolds Number - ratio of inertial to viscous forces)
- Pr = Cp μL / kT (Prandtl Number - ratio of momentum diffusivity to thermal diffusivity)
- ho: Broth-side film heat transfer coefficient (target value, e.g., W/(m²·K)).
- dT: Tank diameter (e.g., m).
- kT: Liquid thermal conductivity (e.g., W/(m·K)).
- di: Impeller diameter (e.g., m).
- N: Agitation speed (e.g., rev/s).
- ρL: Liquid density (e.g., kg/m³).
- μL: Liquid viscosity at bulk temperature (e.g., Pa·s).
- Cp: Liquid specific heat capacity (e.g., J/(kg·K)).
- μLw: Liquid viscosity at wall temperature (e.g., Pa·s).
The constants C and a depend on the configuration: